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KMID : 1134820100390081107
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Journal of the Korean Society of Food Science and Nutrition
2010 Volume.39 No. 8 p.1107 ~ p.1112
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Antiproliferation Effects of Ethanol and Water Extracts from Germinated Rough Rice
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Kim Hyun-Young
Hwang In-Guk
Kim Tae-Myoung
Kim Dae-Joong
Park Dong-Sik
Kim Jae-Hyun
Lee Jun-Soo
Jeong Heon-Sang
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Abstract
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This study was conducted to investigate the effect of 70% ethanol and water extract of Korean rough rice (‘Ilpum’, ‘Goami2’, ‘Keunnun’, ‘Sulgaeng’, ‘Baegjinju’, and ‘Heugkwang’) before and after germination on proliferation of human cancer cell lines (HepG2, PC-3, and MCF-7). Antiproliferation effect was higher in ethanol extract than water extract, and was higher in after germination. ‘Ilpum’ ethanol extract after germination showed higher anti-proliferation effect on HepG2 and PC-3 cell lines than before germination. The cell viability on HepG2 and PC-3 cell lines of ‘Ilpum’ ethanol extract after germination was 27.23% and 5.05% at 1.0 ㎎/mL, respectively. The anti-proliferation effect on MCF-7 was the highest in ‘Ilpum’ and ‘Heugkwang’ 70% ethanol extract after germination and those cell viabilities were 7.27% and 17.00% at 0.5 ㎎/mL, respectively. These results suggest that germinated rough rice might have a potentially preventive effect on human cancer cells.
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KEYWORD
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rough rice, germination, antiproliferation, human cancer cell lines
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